番剧百科基本内容
张晓东性别：男职称：开大学生命科学学院教授所属部门：生物化学和分子生物学系招生专业： 生化与分子生物学
研究方向：肿瘤分子生物学，探讨乙肝病毒致癌分子机制和乳腺癌转移分子机制,筛选抗肿瘤药物
现任南开大学生命科学学院教授，博士生导师，分子生物学研究所肿瘤研究室主任,中组部国家“千人计划”入选者。
日本东京大学分子细胞生物学研究所JSPS博士后;第四军医大学病理学专业博士
研究领域：肿瘤分子生物学，开展乙肝病毒致癌分子机制和乳腺癌转移分子机制研究，筛选抗肿瘤药物
科研成果
国家科技进步奖二等奖：《人原发性肝癌发病机制的免疫病理学和分子病理学研究》
陕西省科技进步奖一等奖：《肝炎、肝硬变和肝癌发病关系的免疫病理学和分子病理学研究》
社会兼职
中国抗癌协会肿瘤标志委员会常委，天津市抗癌协会常务理事，千人计划联谊会生命科学与生物医药专业委员会委员，天津滨海新区抗癌新药创制产业技术战略联盟理事长，大连医科大学客座教授,兰州大学第二医院/第二临床医学院客座教授。Oncogene,PLoS ONE等杂志审稿人。
回国后获得基金和研究生培养情况
2000年11月回国，先后获得并参加973计划项目2项（1项为课题组组长）、主持国家自然科学基金4项,参加国家自然科学基金7项，主持天津市科技发展计划科技攻关项目4项。目前，培养博士生15人（毕业10人)，硕士生27人（毕业19人）。目前，已获得国家发明专利2项。回国后在国内外学术刊物上共发表论文70余篇，其中SCI论文50余篇(影响因子累计大于180）,影响因子大于10的1篇，大于9的2篇，大于5的8篇。
获得授权专利
1.叶丽虹,张晓东,吴莲英,朱惠芳.高转移倾向的人乳腺癌细胞系及其建立方法，获得国家发明专利.
2.叶丽虹,张晓东,秦宵然,朱惠芳，王洪辉.人肝癌转移亚克隆细胞系及其建立方法，获得国家发明专利.
:主要学术论文::
张晓东;东楠;殷丽辉;蔡娜;马宏涛;尤嘉琮;张航;王洪辉; He, R;. Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues. JOURNAL OF MEDICAL VIROLOGY
张晓东;东楠;张航;尤嘉琮;王洪辉;叶丽虹. Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cel. JOURNAL OF LABORATORY AND CLINICAL MEDICINE
王凤泽;沙丽;乔玲;吴莲英;张晓东;叶丽虹. Promotion of transcriptional activity of NF-kappa B mediated by HBXIP in hepatoma cells. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
秦宵然;张航;周晓雷;王长晔;张惠中;张晓东;叶丽虹. Proliferation and migration mediated by Dkk-1/Wnt/beta-catenin cascade in a model of hepatocellular carcinoma cells. TRANSLATIONAL RESEARC
张晓东;张伟英;叶丽虹. Pathogenesis of hepatitis B virus infection. FUTURE VIROLOGY
乔玲;徐治立;谭旭;叶丽虹;张晓东. Investigation of inhibition of Wnt/beta-catenin pathway in breast cancer cells mediated by Dkk-1 released from human mesenchymal stem cells. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
王凤泽;沙丽;张伟应;吴莲英;乔玲;李楠;张晓东;叶丽虹. Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells. ACTA PHARMACOLOGICA SINICA
张晓东;张航;吴莲英;沙丽;刘树业;邵新华;叶丽虹. Anti-HBx in sera is a potential marker of development from hepatitis B (HB) to liver cirrhosis (LC) and hepatocellular carcinoma (HCC). JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
叶丽虹;蔡娜;东楠;李楠;张伟英;张航;张烜;吴莲英;张晓东. Interference of RNA targeting hepatitis B virus x (HBx) gene reduces the tumorigenicity of hepatoma cells and HBx-transformed human liver cells. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
张晓东;蔡娜;李楠;张伟英;张航;张烜;吴莲英;齐众;叶丽虹. Transformation of human normal liver L-O2 cells induced by hepatitis B virus X protein, enhanced by highly expression level of survivin as a co-factor. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Zhang, XD; Zhang, H; Ye, LH. Effects of hepatitis B virus X protein on the development of liver cancer. JOURNAL OF LABORATORY AND CLINICAL MEDICINE 147-2-58.2006-1-1
Zhang H, Wu LY, Zhang S, Qiu LY, Li N, Zhang X, Zhang XZ, Shan SL, Ye LH, Zhang XD*.Anti-hepatitis B Virus (HBV) X protein (HBx) in sera is one of the markers of development of liver c. J Biomed Biotechnol
Zhang WY, Cai N, Ye LH, Zhang XD. Transformation of human liver L-O2 cells mediated by stable HBx transfection.. Acta Pharmacol Sinica.
Zhang WY, Xu FQ, Shan CL, Xiang R, Ye LH, Zhang XD. Gene expression profiles of human liver cells mediated by hepatitis B virus X protein. Acta Pharmacologica Sinica
You J, Mi D, Zhou X, Qiao L, Xu S, Zhang X, Ye LH. Positive feedback between activated ERK and COX/LOX contributes to breast cancer cell proliferation . Endocrinology
Zhou X, Liu Y, You J, Zhang X, Ye LH. Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2. . Cancer Letters 270–312-327.2008-11-8
Qiao L, Xu ZL, Zhao TJ, Ye LH, Zhang XD. Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling. Cancer Letters
张学智,山长亮,叶丽虹,张晓东. RNA干扰在抗乙肝治疗中的应用及其研究进展. . 生物化学与生物物理进展
Qiao L, Xu Z, Zhao T, Zhao Z, Shi M, Zhao C, Ye L, Zhang X. Depression of tumorigenesis mediated by human mesenchymal stem cells in a model of hepatoma cells.. Cell Res
Ye LH, Dong N，Wang Q，Xu ZL，Cai N，Wang HH，Zhang X. Progressive changes in hepatoma cells stably transfected with hepatitis B virus X gene. Intervirology
Zhang H, Shan C, Li N, Zhang X, Zhang X, Xu F, Zhang S, Qiu L, Ye L, Zhang X. Identification of a natural mutant of HBV X protein truncated 27 amino acids at COOH-terminal and it. Acta Pharmacologica Sinica
Qiao L, Zhao T, Wang F, Shan C, Ye L, Zhang X. NF-κB downregulation maybe involved the depression of proliferation of tumor cells mediated by human mesenchymal stem cells. . Acta Pharmacologica Sinica,
Wang F, Sha L, Ye L*, Zhang X. Promotion of cell proliferation by HBXIP via upregulation of human telomerase reverse transcriptase in human mesenchymal stem cells. . Acta Pharmacologica Sinica
张烜，叶丽虹，张晓东. 骨桥蛋白通过NF-kB上调钙蛋白酶小亚基1促进肝癌细胞迁移. 生物化学与生物物理进展
Cui WJ, Liu Y, Zhou XL, Wang FZ, Zhang XD, Ye LH. Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway. Acta Pharmacol Sin.
Zhang X, Ye LH, Zhang XD. A mutant of hepatitis B virus X protein (HBx?127) enhances cell migration via osteopontin (OPN) invo. Acta Pharmacol Sin.
Zhang F, Wang Q, Ye LH, Feng YM, Zhang XD. Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kap. J Med Virol.
Shan C, Xu FQ, Zhang S, You JC, You XN, Qiu LY, Zheng J, Ye LH, Zhang XD. Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2. Cell Res.
Wang Q, Zhang WY, Ye LH, Zhang XD. A mutant of HBx (HBxΔ127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase. Acta Pharmacol Sin.
Wang Q, Zhang W, Liu Q, Zhang X, Lv N, Ye L, Zhang XD. A Mutant of Hepatitis B Virus X Protein (HBxDelta127) Promotes Cell Growth through A Positive Feedba. Neoplasia
Zhou XL, Qin XR, Zhang XD, Ye LH. Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/β-catenin signaling. Acta Pharmacol Sin.
Cui WJ, Zhang YW, Hu N, Shan CL, Zhang S, Zhang WY, Zhang XD, Ye LH. MiRNA-520b and miR-520e sensitize breast cancer cells to complement attack via directly targeting 3u2032. Cancer Biol Ther.
张烜，叶丽虹，张晓东. 乙肝病毒X蛋白通过骨桥蛋白OPN促进肝癌细胞迁移. 中国生化与分子生物学学报26-4-
周晓雷，张晓东,叶丽虹. DKK-1通过上调nm23表达抑制乳腺癌细胞迁移。. 中国生化与分子生物学学报 26-2-
Wang Q, Zhang T, Ye LH*, Wang WH, Zhang XD.. Analysis of hepatitis B virus X gene (HBx) mutants in tissues of patients suffered from hepatocellular carcinoma inChina. Cancer Epidemiology –.
Zhang S, Shan CL, Kong GY, Du YM, Ye LH*, Zhang XD*. MicroRNA-520e suppresses growth of hepatoma cells by targeting the NF-κB-inducing kinase (NIK). Oncogene
Kong G, Zhang J, Zhang S, Shan C, Ye LH*, Zhang XD*. Upregulated MicroRNA-29a by Hepatitis B Virus X Protein Enhances Hepatoma Cell Migration by Targetin. PLoS One 6-5
Kong GY, Zhang JP, Zhang S, Shan CL, Ye LH*, Zhang XD*.. Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2. Acta Pharmacol Sin.
张煊;叶丽虹*;张晓东*. Osteopontin(OPN) Upregulates Calpain Small Subunit 1(Capn4) via Nuclear Facter-kappa B in Promotion of Hepatoma Cell Migration. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 37-5-534.2010-1-1
尤嘉琮，米达，周晓雷，乔玲，张航，张晓东*，叶丽虹*. A Positive Feedback between Activated Extracellularly Regulated Kinase and Cyclooxygenase/Lipoxygenase Maintains Proliferation and Migration of Breast Cancer Cells. ENDOCRINOLOGY 150-4-1607-1617.2009-1-1
Zhang Xue-Zhi; Shan Chang-Liang; Ye Li-Hong; Zhang Xiao-Dong. Advantages of RNA interference in anti-hepatitis B virus therapy. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 35-6-631.2008-1-1
Nan HU, Yu LI, Yu ZHAO, Qi WANG, Jia-cong YOU, Xiao-dong ZHANG, Li-hong YE. A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cells. ACTA PHARMACOLOGICA SINICA 32–921-929.2011-1-1
Changliang Shan, Shuai Zhang, Wenjing Cui, Xiaona You, Guangyao Kong, Yumei Du, Liyan Qiu, Lihong Yeand Xiaodong Zhang. Hepatitis B virus X protein activates CD59 involving DNA binding and let-7i in protection of hepatoma and hepatic cells from complement attack. Carcinogenesis
Hu N, Zhang J, Cui W, Kong G, Zhang S, Yue L, Bai X, Zhang Z, Zhang W, Zhang X, Ye L.. miR-520b Regulates Migration of Breast Cancer Cells by Targeting Hepatitis B X-interacting Protein and Interleukin-8. J Biol Chem
张涛,张俊萍,由晓娜,刘迁,杜玉梅,高玉恩,山长亮,孔光耀,叶丽虹，张晓东.Hepatitis B Virus X Protein (HBx) Modulates OncogeneYAPvia CREB to Promote Growth of Hepatoma Cells. . Hepatology
杜玉梅,孔光耀由晓娜,张帅，张涛,叶丽虹,张晓东. Up-regulated long non-coding RNA HULC by HBx enhances growth of hepatoma cells via down-regulating p18.. J Biol Chem.
Zhang X, You X, Wang Q, Zhang T, Du Y, Lv N, Zhang Z, Zhang S, Shan C, Ye LH, Zhang XD. Hepatitis B virus X protein promotes cell migration via multiple cross-talk cascade loops involving . PLoS One 2012;7(2):e
Zhang W, Kong G, Zhang J, Wang T, Ye LH, Zhang XD. MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and Cyclin D1. PLoS One 2012;7(2):
Cui W, Zhao Y, Shan C, Kong G, Hu N, Zhang Y, Zhang S, Zhang W, Zhang XD, Ye LH. HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-κB signaling to protect breast cancer cells . FEBS Letters
Zhao Y, Wang W, Wang Q, Zhang XD, Ye LH. Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor. Biochem Biophys Res Commun.
Zhang X, You XN, Li N, Zhang WY, Gagos S, Wang Q, Banos A, Cai N, Zhang HK, Zhang H, Zhang XZ, Shan CL, Qiu LY, Zhang S, Lv N, Chen MS, Du YM, Xia JC, Ye LH*, Zhang XD*. Involvement of hepatitis B virus X gene (HBx) integration in hepatocarcinogenesis via a recombination of HBx/Alu core sequence/subtelomeric DNA. FEBS Letters
Liu SP, Li LL, Zhang YY, Zhang YW, Zhao Y, Lin ZH, Zhang XD*, Ye LH*. HBXIP upregulates s100a4 via stat4 and pten to promote growth and migration of breast cancer cells. J Biol Chem
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